The experimental drug analysis

Date of publication:2012-11   Press: Chinese medical science and Technology Press   Author:Sun Lixin   Pages:177   Words:238000  
Summary

The copyright page: illustration: (two) aspirin enteric coated tablets full inspection the goods with aspirin (C9H8O4) should be marked in the amount of 93% to 107%. The 1 character is enteric coated tablets were removed after coating of white. 2 differential (1) fine powder take the goods amount (equivalent to about aspirin 0.1g), add 10ml of water, boil, cool, add 1 drops of ferric chloride solution, a violet colour is. (2) in the determination of chromatogram recorded under, the retention time of test sample solution should be consistent with the retention time of the main peak of the peak of the reference solution. 3 check (1) free salicylic acid to take the product of fine powder (roughly the equivalent of aspirin 0.1g), accurately weighed, into 100ml volumetric flask, shaking the methanol solution with 1% acetic acid induced the aspirin dissolved and diluted to the scale, shake, membrane filtration, and the filtrate as the test.Solution (pro with new system); water salicylic acid standard about 15mg, accurately weighed, into 50ml volumetric flask, methanol solution dissolved and diluted to the scale, shake with 1% acetic acid and the precise amount of 5ml, into 100ml volumetric flask, 1% methanol solution of acetic acid diluted to the scale, shake, as as the reference solution. Method for the determination of free salicylic acid in aspirin under, by external standard method and calculated by peak area, shall not exceed 1.5% of the labeled amount. (2) release acid release to take this product, according to release assay, the method for determination of solubility of the first device, with 600ml hydrochloric acid solution 0.1 mol / L (25mg, 40mg, 50mg specifications) or 750ml (100mg, 300mg specifications) solution, rotating speed of 100r / min and in accordance with the law, by 2H, the solution 10ml, filtration, the filtrate from continued as the test solution; taking aspirin control sample, accurately weighed, plus 1% glacial acetic acid methanol solution dissolved and diluted into each 1ml containing 4.25 μ g (25mg specifications), 7 μ g (40mg specifications), 8.25 μ g (50mg specifications), 13 μ g (100mg specifications), 40 μ g (300mg specifications) solution as the reference solution. According to the determination method for the content determination of under. The release amount of calculation in each tablet of aspirin, aspirin limit should be less than 10% of the labeled amount of. The release amount of buffer release of 0.2mol / L sodium phosphate solution 200ml solution is to add a check under 37 ℃ in acid (25mg, 40mg, 50mg specifications) or 250ml (100mg, 300mg specifications), mixing, adjusting the solution with 2mol / L or 2mol / L hydrochloric acid solution of sodium hydroxide solution pH value to 6.8 ± 0.05, continue to release 45min, the solution 10ml, filtration, the filtrate from continued as the test solution; the other to take aspirin control amount of goods, accurately weighed, dissolved in methanol glacial acetic acid and diluted into each 1ml containing 22 μ g (25m9 specifications), 35 μ g (40mg specifications), 44 μ g (50mg specifications), 72 μ g (100mg specifications), 0.2mg (300mg specifications) solution as aspirin reference solution; another salicylic acid control sample, accurately weighed, plus 1% glacial acetic acid methanol solution dissolved and diluted into each 1ml containing 1.7 μ g (25mg specifications), 2.6 μ g (40mg specifications), 3.4 μ g (50mg specifications), 5.5 μ g (100mg specifications), 16 μ g (300mg specifications) solution of salicylic acid, as the reference solution.
Catalogue of books

The first part of the basic knowledge of
the first pharmaceutical analysis experimental record and report
second analytical balance operation procedures
third capacity calibration of the instrument
Fourth significant figures and rounding
second validation experiments
the typical chemical medicine and preparation of
experiment two glucose identification test a general examination of impurity
experiment three typical chemical medicine special impurities and related substances
the gas chromatography method for the determination of residual solvents in dexamethasone sodium phosphate dexamethasone acetate tablets five
the content uniformity test of
experiment six acid dye colorimetric method for the determination of atropine sulfate tablets by
experiment seven oxygen bottles combustion method for the determination of halogen containing the drug content of
eight three point correction a UV spectrophotometric method for the determination of vitamin A soft capsule content
nine compound acetyl salicylic acid the content determination of
experiment ten dual wavelength UV spectrophotometric method for the determination of compound sulfamethoxazole tablets
experiment eleven fluorescence spectrophotometric method for the determination of Pipemidic Acid Tablets twelve
the HPLC method for content determination of Norfloxacin Capsules
. Test thirteen gas chromatography method for the determination of vitamin E powder content in the
experiment fourteen iodometric method for the determination of sodium sulfite anhydrous content
experiment fifteen typical Chinese herbal medicine and traditional Chinese medicine preparation identification test of
experiments of sixteen typical Chinese herbal medicine and traditional Chinese medicine preparation of the characteristic components or related substances
seventeen experiments in gas chromatographic determination medicinal materials of volatile components in
experiment eighteen HPLC method for the determination of active ingredients in the preparation of traditional Chinese medicine.
nineteen experiments by gas chromatography / mass spectrometry method for identification of Chinese medicinal materials of volatile components in
third part comprehensive experimental
experiment twenty penicillin sodium full test of
experiment twenty-one aspirin and enteric coated tablets of all
in experiment twenty-two, vitamin B, slices of whole test
experiment twenty-three glucose injection
full test experiment twenty-four hydrocortisone cream full test of
experiment twenty-five compound aluminium hydroxide tablets full test of
twenty-six experiment of compound levonorgestrel tablets full test of
experiment twenty-seven propylene glycol full test of
twenty-eight Fructus aurantii full inspection.
experiment twenty-nine Chinese haw leaf extract full test of
. Test thirty Tianshu capsule full test of
fourth part design experiment of
experiment thirty-one non aqueous titration method for the determination of drug content methodology
experiment thirty-two UV spectrophotometric method for the determination of drug content methodology
experiment thirty-three HPLC method for the determination of drug content method research
fifth part of open experiment
thirty-four B adrenoceptor blocking drug quality standard
sixth part analysis of drugs in vivo experimental
thirty-five UV visible spectrophotometric method for the determination of paracetamol in human saliva concentration
experiment thirty-six fluorescence spectrophotometric method for the determination of ampicillin in human urine the concentration of
experiment thirty-seven HPLC method for determination of plasma concentration of salicylic acid in aspirin metabolite
experiment thirty-eight HPLC method for the determination of human plasma probenecid concentration
experiment thirty-nine HPLC method for the determination of paracetamol in human plasma pharmacokinetic parameters
experiment forty high performance liquid chromatographic method for the determination of gatifloxacin in rats in vivo tissue distribution of
experiment forty-one high performance liquid Determination of analytical method validation guidelines
appendix two pharmaceutical human bioavailability and bioequivalence test guideline
reference @##@ in rat plasma methyl nonyl ketone concentration
appendix related guidelines
appendix a drug quality standard chromatography mass spectrometry studies Ni Mei Shug Leigh dispersible tablets in human bioequivalence
experiment forty-two gas chromatography mass spectrometry "Pharmaceutical experimental teaching material of national medical colleges and Universities: Pharmaceutical Analysis Experiment" is one of the pharmacy experimental teaching in higher medical institutions. The medical institutions of higher learning materials according to the drug analysis and pharmaceutical analysis in vivo experiment curriculum syllabus requirements prepared. The book is divided into 7 parts, including the basic knowledge, experiment, comprehensive experiment, designed experiment, open experiment, in vivo drug analysis and appendix. The book consists of 42 experiments, including the capacity analysis, UV visible spectrophotometry, fluorescence spectrophotometry, thin layer chromatography, high-performance liquid chromatography, gas chromatography, high performance liquid chromatography mass spectrometry and gas chromatography / mass spectrometry method. "The experimental drug analysis (pharmacy experiment teaching material of national medical colleges of Pharmacy)" for medical colleges and universities and related professional graduate, undergraduate teaching, but also can be used as staff drug inspection reference book.
Chapter excerpt

"Pharmaceutical experiment teaching material of national medical colleges in pharmaceutical analysis teaching research experiment" for pharmacy in higher medical institutions and related professional students, staff, also can be used as drug testing reference book.
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