Inset: the innate immune response is also called innate immunity (innate immunity), innate immunity (natural immunity) or non specific immunity (nonspecific immunity), is a kind of innate immune defense function of the body gradually formed in a phylogenetic and evolutionary process, the first line of defense against pathogens constituting the machine body of biological invasion. Innate immune response by innate immune cells and molecules mediating, its main characteristic is the molecular expression of innate immune cells recognize a variety of "non self" foreign bodies, but not the epitopes, which, for a variety of pathogenic microorganisms or their products can be quickly response, and immune effect. Innate immune cells do not express the specific antigen recognition receptor, but innate immune cells is the cell surface receptor expression in molecular recognition, pattern of a variety of pathogens at the surface of the activated signal transduction, the special way, without the clonal expansion of the circumstances, produce effector molecules, rapid immune effect. Participate in the innate immune response substances mainly include: organizational barrier, innate immune cells and the innate immune molecules. Phagocytic cells can be non-specific phagocytosis and killing pathogenic microorganism, NK cells (natural killer cells), NIT cells, 78T cells can kill tumor cells and virus-infected cells; the innate immune cells by secreting cytokines have different different immunomodulatory effects or mediated inflammatory reaction. Play an important role in innate immune molecules in the organism anti infection immune process, innate immune response in innate immune cells and molecular synergistic action of. The innate immune response can be divided into transient innate immune response, the early innate immune response and the induction of adaptive immune responses in three stages. Innate immune cells through the surface pattern recognition receptors (pattern recognition receptor, PPR) with direct identification pathogens to be activated, and without the clonal expansion rapidly under immunity, in the process of immune response, cannot form the immune memory. Innate immune response initiating adaptive immune responses, can affect the type of adaptive immune response, and to assist in the adaptive immune response immune effect. Cells and molecules involved in the innate immune response will be elaborated in the following content, the paper introduces the role of innate immune responseThe phase, and its relations with the adaptive immune response.
Viral immunology is a cross disciplinary science explore the interactions between the virus and the host immune system. It not only combines the related content of Virology, molecular virology, immunology, continued integration of new theories and viewpoints of molecular cell biology and genetics. Since twentieth Century, the virus immunology is one of the fastest growing areas in life science, molecular biology, since the establishment of new technology and method to improve and perfect, a large number of new theory and new concepts, especially the new theory of the immune system, greatly promoted the study of viral immunology, there is great breakthrough in the viral genome structure, pathogenic mechanism and control methods. "Virus Immunology" is to introduce a system of subject virus immunology contemporary medical and life science is one of the few professional reference book. Study of the current human AIDS and viral hepatitis and other viral infectious diseases have been included in China's "eleven five" major infectious disease research special plan, and the important content in the research of immune mechanism of the viral diseases. This book introduces the important common human virus (human immunodeficiency virus, hepatitis virus, influenza virus) in innate and adaptive immune mechanism, combined with the methods and means of immunology research, introduces the participation in various immune cells, immune active molecules antiviral effect and mechanism of effect, also introduced the current international frontiers in this field, is one of the existing theory, and combined with the practical books research methods, can be used as a text for graduate students, is also suitable for the majority of scientific researchers. I hope this book can become the link between immunology and virology, and be able to make the two disciplines to establish closer ties. Participate in the writing staff includes many returned overseas students, professors and researchers, they have a wealth of experience in virology, immunology and molecular biology, teaching and scientific research, and has made outstanding achievements in scientific research in virus immunology.
The first part of the innate immune mechanisms of virus infection in first chapter virus infection in the second chapter of innate antiviral innate immune cells the third chapter antiviral innate immune molecule fourth chapter and sixth chapter complement virus infection virus infection of humoral immunity in Chapter seventh virus-infected cells by the eighth chapter virus persistent infection and immune suppression of the third part the interaction between virus and cells in Chapter ninth, virus infection and cell receptor starting tenth chapter virus cell interaction with the eleventh chapter virus on the host toxicity of twelfth chapter, thirteenth chapter of host susceptibility to the virus infection of hepatitis B virus immune chapter fourteenth of hepatitis C virus infection of influenza virus infection fifteenth chapter seventeenth chapter of measles virus other common virus fifth virus immune control of the eighteenth chapter of antiretroviral therapy in nineteenth chapter twentieth chapter virus vaccine emerging viral diseases prevention and control twenty-first chapter of persistent viral infections @##@ new countermeasures This book introduces the latest virus immunology theory, introduces the virus infection and host resistance to infection of the general rules, theory and immune prevention are expounded, and a variety of common human important viral infection immune mechanism. This book introduces the basic knowledge of the virus immunology at the same time, focus on the latest development with virological and immunological theory and research method, provide a good platform for the study of Microbiology, virology, immunology and medical scholars. The content of this book explain profound theories in simple language, illustrated. The content includes: the innate immune system of virus infection; adaptive immune mechanisms of viral infection; the interaction of virus and cell; the common human important viral infection immune mechanism and immune control of the virus. This book is available in virology, immunology research reference, can also be used as a graduate textbook for immunology graduate.
"Virus Immunology" by the scientific publishing house.
Medical Science @ 2017